sbeadex™ magnetic microparticles enable the automated high-throughput extraction and purification of high quality DNA and RNA preparations from a wide range of materials including plant, blood, cells and tissues, bacteria, viruses and forensic material.
learn moreHigh-throughput, cost-effective nucleic acid isolation from a broad range of sample materials.
learn moreSample material can vary greatly in consistency as well as in sugar, protein and fat composition - all of which can affect the quality and purity of the isolated nucleic acid and the subsequent performance of downstream applications. To provide the most efficient and effective purification method, LGC Biosearch Technologies offers not only a range of different extraction chemistries/technologies but also the capacity to develop tailor-made kit systems optimised to a particular sample type/matrix and/or application.
| sbeadex™ | mag™ | MasterPure™ | |
|---|---|---|---|
| Purification technology |
Surface-modified superparamagnetic particles |
Modified superparamagnetic particles |
Solution-based precipitation chemistry |
| Mechanism of action | Novel two-step binding mechanism(1) | Classic polarity-based binding mechanism | Cell debris, proteins and DNA are precipitated and separated using highly concentrated salt solutions and isopropanol |
| Format | Single tubes and multi-well plates | Single tubes and multi-well plates | Single tubes and multi-well plates |
| Flexibility | Scalable protocols, adaption to any sample material (lysis) | Scalable protocols, adaption to any sample material (lysis) | Scalable protocols. adaption of volume |
| Matrices | Plant material, forensic samples, tissue and cells, bacterial cultures, blood, saliva, swab, plasma, serum, urine etc. | Whole blood, buffy coat, buccal swabs, saliva, bacteria, yeast, fungi, plant material, animal tissue, microorganisms etc. | Cultured cells, tissue/paraffin-embedded tissue, blood, serum, plasma, saliva, sputum, urine, yeast, bacteria, plant material etc. |
| Grade of automation | Automated high-throughput extraction on common liquid handling systems | Automated high-throughput extraction on common liquid handling systems |
Semi-automated extraction (centrifugation required) on common liquid handling systems |
| Benefits |
• Highest-quality DNA and RNA suited for many downstream applications • No organic solvents or chaotropic salts in final wash buffers • No drying of beads for evaporation of alcohols • High flexibility of all extraction parameters |
• High-quality DNA suited for many downstream applications • High flexibility of all extraction parameters • High yields • Very cost-effective |
• High-quality DNA & RNA suited for many downstream applications • Suited for purification of High-Molecular-Weight (HMW) DNA for long-read sequencing • Wide range of sample types • High yields • Safe and gentle protocol without hazardous chemicals |
(1) Our surface-coated superparamagnetic particles do not require the use of vacuum filtration or centrifugation steps, hence they are well-suited to automation.
For research use only. Not for use in diagnostic procedures.
