Nucleic acid purification kits

We offer innovative superparamagnetic bead-based and solution-based nucleic acid purification technologies for fast and convenient isolation of high-quality DNA and RNA from a broad range of sample materials and species.

sbeadex nucleic acid purification technology

sbeadex™ magnetic microparticles enable the automated high-throughput extraction and purification of high quality DNA and RNA preparations from a wide range of materials including plant, blood, cells and tissues, bacteria, viruses and forensic material.

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sbeadex PCR clean-up Kit

The sbeadex™ PCR clean-up kit is used to purify PCR products for sensitive downstream applications. Components of the PCR reaction such that primers, unincorporated nucleotides, enzymes and other contaminations are efficiently removed and the protocol can be scaled up or down for other volumes of PCR product.

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sbeadex Tissue DNA Purification Kit

The sbeadex™ Tissue DNA Purification Kit is ideally suited to isolate high-quality nucleic acids from a wide range of mammalian tissues and cultured cells (e.g. skin, lung, muscle, spleen, mouse tails, ear punches) which can be used in downstream applications such as PCR or sequencing.

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sbeadex Plasmid DNA Purification Kit

The sbeadex™ Plasmid DNA Purification Kit is used to isolate plasmid DNA from bacterial cultures (e.g. E. coli). They have been optimised for automated high-quality plasmid DNA isolation that is suitable for many downstream applications such as cloning, restriction analysis, in vitro transcription, cell transformation/transfection, nucleic acid labeling, PCR, DNA sequencing.

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sbeadex Plant DNA Purification Kits

The sbeadex™ Plant DNA Purification Kits are used to isolate DNA from a wide variety of plant species and materials. They have been optimised for automated high-quality DNA isolation from both fresh and lyophilised plant tissue material including leaves, seeds, fruits, pulp, bark and roots.

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sbeadex Forensic DNA Purification Kit

The sbeadex™ Forensic DNA Purification Kit enables isolation of high-quality DNA from a wide variety of forensic sample types, including blood stains, hair, semen and saliva from e.g. clothing, chewing gum and clothing.

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sbeadex Pathogen Nucleic Acid Purification Kit

High-throughput, high-quality DNA and RNA purification for detection of multiple pathogens

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sbeadex Livestock DNA Purification Kit

sbeadex livestock kits produce high-quality DNA. Blood, hair, semen, ear punches, saliva and swabs are used for analysis of a huge diversity of animal species.

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sbeadex Blood DNA Purification Kit

sbeadex™ magnetic microparticles enables the automated high-throughput extraction and purification of high quality DNA preparations from blood.

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mag Nucleic Acid Purification Kits

High-throughput, cost-effective nucleic acid isolation from a broad range of sample materials.

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Proteinase K

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Sample material can vary greatly in consistency as well as in sugar, protein and fat composition - all of which can affect the quality and purity of the isolated nucleic acid and the subsequent performance of downstream applications. To provide the most efficient and effective purification method, LGC Biosearch Technologies offers not only a range of different extraction chemistries/technologies but also the capacity to develop tailor-made kit systems optimised to a particular sample type/matrix and/or application.

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Key features of each purification technology

	sbeadex™	mag™	MasterPure™
Purification technology	Surface-modified superparamagnetic particles	Modified superparamagnetic particles	Solution-based precipitation chemistry
Mechanism of action	Novel two-step binding mechanism⁽¹⁾	Classic polarity-based binding mechanism	Cell debris, proteins and DNA are precipitated and separated using highly concentrated salt solutions and isopropanol
Format	Single tubes and multi-well plates	Single tubes and multi-well plates	Single tubes and multi-well plates
Flexibility	Scalable protocols, adaption to any sample material (lysis)	Scalable protocols, adaption to any sample material (lysis)	Scalable protocols. adaption of volume
Matrices	Plant material, forensic samples, tissue and cells, bacterial cultures, blood, saliva, swab, plasma, serum, urine etc.	Whole blood, buffy coat, buccal swabs, saliva, bacteria, yeast, fungi, plant material, animal tissue, microorganisms etc.	Cultured cells, tissue/paraffin-embedded tissue, blood, serum, plasma, saliva, sputum, urine, yeast, bacteria, plant material etc.
Grade of automation	Automated high-throughput extraction on common liquid handling systems	Automated high-throughput extraction on common liquid handling systems	Semi-automated extraction (centrifugation required) on common liquid handling systems
Benefits	• Highest-quality DNA and RNA suited for many downstream applications • No organic solvents or chaotropic salts in final wash buffers • No drying of beads for evaporation of alcohols • High flexibility of all extraction parameters	• High-quality DNA suited for many downstream applications • High flexibility of all extraction parameters • High yields • Very cost-effective	• High-quality DNA & RNA suited for many downstream applications • Suited for purification of High-Molecular-Weight (HMW) DNA for long-read sequencing • Wide range of sample types • High yields • Safe and gentle protocol without hazardous chemicals

⁽¹⁾ Our surface-coated superparamagnetic particles do not require the use of vacuum filtration or centrifugation steps, hence they are well-suited to automation.

For research use only. Not for use in diagnostic procedures.